15 - ANTICOAGULANTS

Item Number: 10968 correct answer: 2 category: Anticoagulants

1. A patient diagnosed with a deep venous thrombosis is begun on a heparin

infusion of 1000 U/HR after a 5000 U Bolus. The earliest you can draw blood

for an aPTT reflecting steady-state heparin is:

1. 4 hours

2. 7.5 hours

3. 12 hours

4. 24 hours

5. None of the above

Item Number: 10973 correct answer: 2 category: Anticoagulants

2. The direct-acting plasminogen activator is:

1. streptokinase

2. urokinase

3. epsilon-aminocaproic acid

4. anistreplase

5. heparin

Item Number: 10980 correct answer: 4 category: Anticoagulants

3. The antithrombotic drug which inhibits cyclooxygenase enzymes is:

1. prednisone

2. dipyridamole

3. tranexamic acid

4. aspirin

5. ticlopidine

Item Number: 10983 correct answer: 3 category: Anticoagulants

4. Correct statements about the action of warfarin include:

A. warfarin is structurally similar to vitamin K and competitively

inhibits liver synthesis of clotting factors

B. warfarin inhibits vitamin K epoxide reductase

C. the onset of warfarin action may be prolonged due to the long

half-life of factor VII

D. factors II, VII, IX, and X are not activated (carboxylated) when

warfarin is administered in therapeutic doses

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10988 correct answer: 3 category: Anticoagulants

5. Drugs which interact with warfarin to increase its anticoagulant effect

include:

A. ranitidine

B. trimethoprim/sulfamethoxazole

C. rifampin

D. nonsteroidal anti-inflammatory drugs

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 11018 correct answer: 1 category: Anticoagulants

6. The mechanism of action of mini-dose heparin is correctly described by:

A. factor X is more sensitive to heparin than are other serine

protease factors

B. mini-dose heparin is useful prophylactically rather than during

active clot formation

C. by inhibiting factor X activation, a relative block of the

clotting cascade develops, with less thrombin formed

D. the major action is to directly inhibit factor II, which is very

sensitive to heparin

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 11041 correct answer: 2 category: Anticoagulants

7. The correct statement about fibrinolytic agents is:

1. streptokinase acts directly to activate plasminogen

2. urokinase acts directly to activate plasminogen

3. tissue-type specific plasminogen activator is more fibrin specific than

streptokinase

4. side effects of t-PA include skin rash, allergic reactions, and

development of antibodies

5. have been shown to increase mortality when given in the setting of an

acute myocardial infarction