9 - ANTITUBERCULARS

Item Number: 714 correct answer: 1 category: Antituberculars

1. The route by which isoniazid is usually administered is:

1. oral

2. intramuscular injection of solution

3. intramuscular injection of suspension

4. subcutaneous injection of solution

5. intravenous

Item Number: 673 correct answer: 3 category: Antituberculars

2. Rifampin is used mainly in the treatment of:

1. cholera

2. typhoid fever

3. tuberculosis

4. rickettsial diseases

5. pseudomonas infections

Item Number: 665 correct answer: 2 category: Antituberculars

3. Impaired vision is an adverse effect of:

1. carbenicillin

2. ethambutol

3. rifampin

4. colistin

5. cycloserine

Item Number: 1595 correct answer: 3 category: Antituberculars

4. Various drugs may induce vitamin deficient states as an undesirable side

effect. Vitam B6 (pyridoxine) deficiency may be related to taking:

1. estrogen-containing oral contraceptives

2. colchicine

3. isoniazid

4. All of the above

5. 1,3

Item Number: 4943 correct answer: 2 category: Antituberculars

5. Most adults who are at high risk of developing pulmonary tuberculosis should

be treated with:

1. isoniazid 100 mg/day for 6 months

2. isoniazid 300 mg/day for 12 months

3. ethambutol 400 mg/day for 12 months

4. rifampin 600 mg/day for 24 months

5. No treatment is necessary

Item Number: 4944 correct answer: 2 category: Antituberculars

6. An antitubercular agent which is associated with the development of ocular

toxicity is:

1. rifampin

2. ethambutol

3. isoniazid

4. streptomycin

5. para-aminosalicylic acid

Item Number: 4945 correct answer: 4 category: Antituberculars

7. Which of the following antitubercular agents is associated with the

development of ototoxicity?

1. rifampin

2. ethambutol

3. isoniazid

4. streptomycin

5. para-aminosalicylic acid

Item Number: 4972 correct answer: 5 category: Antituberculars

8. Which of the following antibiotics is most closely associated with the

development of ocular toxicity?

1. kanamycin

2. penicillin G

3. tetracycline

4. isoniazid

5. ethambutol

Item Number: 4973 correct answer: 4 category: Antituberculars

9. Which of the following antibiotics is most closely associated with the

development of hepatitis?

1. kanamycin

2. penicillin G

3. tetracycline

4. isoniazid

5. ethambutol

Item Number: 4975 correct answer: 1 category: Antituberculars

10. Which of the following antibiotics is most closely associated with the

development of renal and ototoxicity?

1. kanamycin

2. penicillin G

3. tetracycline

4. isoniazid

5. ethambutol

Item Number: 5147 correct answer: 3 category: Antituberculars

11. Which of the following agents used in the treatment of pulmonary tuberculosis

has the side effect of loss of perception of the color green?

1. isoniazid

2. rifampin

3. ethambutol

4. streptomycin

5. para-amino salicylic acid

Item Number: 5148 correct answer: 1 category: Antituberculars

12. Which of the following agents used in the treatment of pulmonary tuberculosis

has a toxicity of producing a lupus-like syndrome?

1. isoniazid

2. rifampin

3. ethambutol

4. streptomycin

5. para-amino salicylic acid

Item Number: 5509 correct answer: 3 category: Antituberculars

13. Isoniazid-induced liver damage:

1. occurs primarily in patients under 30 years of age

2. occurs with increased frequency in patients receiving concomitant

ethambutol therapy

3. is probably due to the formation of a toxic hydrazine metabolite that

binds to liver protein

4. is frequently associated with allergic manifestations such as

eosinophilia, fever, and rash

5. All of the above

Item Number: 9758 correct answer: 4 category: Antituberculars

14. Tubercle bacilli exist in tuberculous patients in three pools extracellular,

intracellular, and necrotic caseum. The only drug which is bactericidal for

all three is:

1. isoniazid

2. ethambutol

3. pyrazinamide

4. rifampin

5. streptomycin

Item Number: 9759 correct answer: 2 category: Antituberculars

15. All of the following are considered primary drugs in the current therapeutic

approaches to the treatment of tuberculosis EXCEPT:

1. streptomycin

2. para-aminosalicylic acid

3. isoniazid

4. rifampin

5. ethambutol

Item Number: 9760 correct answer: 5 category: Antituberculars

16. Which of the following antitubercular drugs has hyperuricemia as one of its

well-documented untoward effects?

1. streptomycin

2. isoniazid

3. cycloserine

4. rifampin

5. pyrazinamide

Item Number: 9761 correct answer: 1 category: Antituberculars

17. Which of the following is a bactericidal antitubercular drug that has an

inhibitory action on cell wall synthesis?

1. isoniazid

2. rifampin

3. ethambutol

4. streptomycin

5. para-aminosalicylic acid

Item Number: 12787 correct answer: 3 category: Antituberculars

18. Ethambutol has become a primary treatment drug in the therapy of tuberculosis

because of its infrequent side effects. The only significant toxic effect is:

1. bone marrow suppression

2. renal tubular damage

3. retrobulbar neuritis

4. hepatitis

5. Stevens-Johnson Syndrome

Item Number: 13119 correct answer: 3 category: Antituberculars

19. Failure of first-line drugs in the initial treatment of apparent pulmonary

tuberculosis may have several causes including poor patient compliance and

atypical mycobacterial infections, the latter usually requiring use of second-

line drugs. All of the following are first-line drugs EXCEPT:

1. streptomycin

2. rifampin

3. ethionamide

4. ethambutol

5. isoniazid