7 - CANCER CHEMOTHERAPY

Item Number: 10115 correct answer: 1 category: Chemotherapy

1. Doxorubicin is associated with:

A. cardiac disease

B. myelosuppression

C. gastrointestinal toxicity

D. nephrotoxicity

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10190 correct answer: 3 category: Chemotherapy

2. Allopurinol is potentially dangerous if used in combination with mercaptopurine because of:

A. inhibition of hypoxanthine-guanine phosphoribosyl-transferase

B. inhibition of xanthine oxidase

C. inhibition of guanylate kinase

D. accumulation of the chemotherapeutic agent

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10155 correct answer: 3 category: Chemotherapy

3. Cyclophosphamide, busulfan, and carmustine all have in common the classification of:

1. antimetabolite

2. antibiotic

3. alkylating agent

4. natural product

5. None of the above

Item Number: 10306 correct answer: 1 category: Chemotherapy

4. The chance for cure with appropriate chemotherapy is best for:

A. Hodgkin's disease

B. choriocarcinoma

C. histiocytic lymphoma

D. pancreatic cancer

E. liver cancer

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10124 correct answer: 4 category: Chemotherapy

5. Hemorrhagic cystitis is associated with:

A. dacarbazine

B. methotrexate

C. cisplatin

D. cyclophosphamide

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10222 correct answer: 3 category: Chemotherapy

6. Chemotherapeutic agents:

A. kill a constant number of cells

B. kill a constant fraction of cells

C. cure most common tumors

D. do not cure many common tumors

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10120 correct answer: 2 category: Chemotherapy

7. Cyclosporin:

A. causes little myelosuppression

B. is useful in treatment of cancers

C. is associated with hepatotoxicity

D. does not cause elevation of serum creatinine

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10220 correct answer: 2 category: Chemotherapy

8. Cyclosporin is used mainly as a (an)

A. immunosuppressive agent

B. treatment for leukemias

C. prophylactic drug in organ transplantation programs

D. treatment for CNS malignancies

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10175 correct answer: 1 category: Chemotherapy

9. Cisplatin is:

A. excreted largely renally, and is nephrotoxic

B. associated initially with hypomagnesemia, hypophosphatemia, hypokalemia, hypocalcemia

C. associated with bone marrow depression

D. associated initially with hypermagnesemia, hypophosphatemia, hyperkalemia, hypercalcemia

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10191 correct answer: 5 category: Chemotherapy

10. Cisplatin may be associated with:

A. electrolyte disturbances

B. nephrotoxicity

C. nausea and vomiting

D. ototoxicity

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10146 correct answer: 1 category: Chemotherapy

11. The rationale for combining various chemotherapeutic agents includes:

A. mechanisms of action are different

B. toxicities are different

C. mechanisms of tumor resistance are different

D. controlled studies in normals have revealed synergistic effects

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 10187 correct answer: 1 category: Chemotherapy

12. Allopurinol is potentially dangerous if used in combination with:

1. mercaptopurine

2. methotrexate

3. cyclophosphamide

4. L-asparaginase

5. cisplatin

Item Number: 10126 correct answer: 4 category: Chemotherapy

13. Congestive heart failure is associated with:

1. cyclophosphamide

2. L-asparaginase

3. cisplatin

4. doxorubicin

5. vincristine