6 - EDNODRINES

Item Number: 10925 correct answer: 1 category: Endocrine

1. Correct statements about the mini-pill include all EXCEPT:

1. it is called the mini-ill because it contains a relatively low dose of

progestin

2. a common side effect of progestin-only pills is spotting, or

breakthrough bleeding

3. its major mechanism of action is to change the character of cervical and

vaginal mucus

4. ovulation does not usually occur if the mini-pill is taken correctly

5. it carries a lower efficacy rate compared to combined oral

contraceptives

Item Number: 10955 correct answer: 3 category: Endocrine

2. Which of the following rows in the chart is (are) correct?

Glucocorticoid Mineralocorticoid Equivalent Duration of action

Potency Potency

A. prednisone 0.8 5.0 MG 8-12 Hours

B. hydrocortisone 1.0 20.0 MG 8-12 Hours

C. dexamethasone 1.0 0.75 MG 18-36 Hours

D. methylprednisolone 0.5 4.0 MG 18-36 Hours

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 7782 correct answer: 2 category: Endocrine

3. Gonadotropins may be used for the treatment of infertility due to pituitary

insufficiency. side effects of gonadotropin administration include:

1. ovarian atrophy and menopausal symptoms

2. multiple births

3. hirsutism

4. ovarian enlargement and rupture

5. adrenal atrophy

Item Number: 10927 correct answer: 3 category: Endocrine

4. Known complications of the combined oral birth control pill (OBCP) include all

EXCEPT:

1. thromboembolic disorders including stroke and MI

2. benign hepatic adenoma

3. growth retardation

4. chloasma

5. weight gain

Item Number: 10958 correct answer: 5 category: Endocrine

5. Correct statements concerning the mechanisms of action of anti-thyroid drugs

include all of the following EXCEPT:

1. PTU inhibits organification and coupling reactions; in addition it

prevents peripheral conversion of T4 to T3

2. iodide prevents dietary iodine uptake and also release of T3 and T4 from

thyroglobulin

3. methimazole inhibits organification and coupling reactions

4. propranolol decreases peripheral T3 formation and decreases heart rate

in patients with thyrotoxicosis

5. lithium is the drug of choice for thyroid storm

Item Number: 7889 correct answer: 5 category: Endocrine

6. 17-alpha alkylation retards hepatic metabolism of and permits oral

administration of androgens. Side effects of prolonged administration:

1. elevations of hepatic transaminase enzymes

2. cholestatic hepatitis and jaundice

3. hepatic adenocarcinoma

4. peliosis hepatitis

5. All of the above

Item Number: 7898 correct answer: 5 category: Endocrine

7. Androgens have been widely abused for their anabolic effects. Therapeutic uses

of androgens include:

1. hypogonadism

2. stimulation of erythropoiesis

3. hereditary angioneurotic edema (17-alpha alkylated analogs)

4. breast carcinoma

5. All of the above

Item Number: 10938 correct answer: 4 category: Endocrine

8. All of the following are progestin components of oral birth control pills

EXCEPT:

1. norgestrel

2. norethindrone acetate

3. ethynodiol diacetate

4. mestranol

5. levonorgestrel

Item Number: 10963 correct answer: 3 category: Endocrine

9. Side effects of thiourea anti-thyroid medications (propylthiouracil and

methimazole) include:

1. hyperthyroidism

2. priapism

3. agranulocytosis

4. SIADH

5. iodism

Item Number: 7994 correct answer: 5 category: Endocrine

10. Flutamide is an anti-androgen. Possible therapeutic uses of anti-androgens

include:

1. male contraception

2. hirsutism and virilization in women

3. acne and baldness in both sexes

4. prostatic cancer

5. All of the above

Item Number: 10939 correct answer: 5 category: Endocrine

11. Dermatologic side effects of corticosteroid therapy include:

1. acne

2. striae, thinning of the skin

3. telangiectasia

4. ecchymosis

5. All of the above

Item Number: 10964 correct answer: 5 category: Endocrine

12. Agents which may be useful for treating hyperthyroidism include all of the

following EXCEPT:

1. propylthiouracil

2. corticosteroids

3. Lugol's solution of potassium iodide

4. propranolol

5. bromocriptine

Item Number: 10943 correct answer: 4 category: Endocrine

13. Correct statements about cortisol synthesis include all of the following

EXCEPT:

1. metyrapone inhibits 11-hydroxylase enzymes, causing an increase in

11-desoxycortisol, a mineralocorticoid

2. ketoconazole inhibits cortisol synthesis

3. aminoglutethimide provides a medical adrenalectomy by inhibiting the

rate-limiting step in cortisol synthesis

4. aminoglutethimide inhibits the conversion of androstenedione to

testosterone

5. trilostane decreases synthesis of both cortisol and aldosterone

Item Number: 7720 correct answer: 2 category: Endocrine

14. A side effects of human biosynthetic growth hormone is:

1. Creutzfeldt-Jakob disease

2. antibody formation

3. hypoglycemia

4. transmission of human immunodeficiency virus

5. hepatitis B

Item Number: 7995 correct answer: 5 category: Endocrine

15. Combined birth control pills are effective contraceptives, but pose risks to

the user. Absolute contraindications to the combined oral contraceptive

include:

1. known or suspected carcinoma of the breast

2. undiagnosed abnormal genital bleeding

3. ischemic heart disease

4. history of thromboembolic disorder

5. All of the above

Item Number: 7778 correct answer: 5 category: Endocrine

16. Several factors or drugs are known to affect growth hormone secretion. Those

drugs that stimulate growth hormone release in normal subjects include all of

the following EXCEPT:

1. clonidine

2. bromocriptine

3. growth hormone releasing hormone

4. serotonin

5. somatostatin

Item Number: 10 correct answer: 1 category: Endocrine

17. Unopposed estrogen use has been associated with tumor development in animals.

Tumors which have been associated with human use of estrogen compounds

include:

A. endometrial cancer

B. breast cancer

C. benign hepatoma

D. malignant melanoma

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 37 correct answer: 5 category: Endocrine

18. Several progestational agents are combined with estrogens in oral

contraceptive pills. Correct statements concerning the actions of progestins

include:

A. several progestins have inherent estrogenic or androgenic effects

B. progesterone administration can prevent ovulation by negative

feedback on LH release

C. progestins inhibit the ÒferningÓ pattern of endocervical

secretions

D. progesterone secretion at the time of ovulation causes a rise in

body temperature of about 1 degree fahrenheit

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 417 correct answer: 3 category: Endocrine

19. Testosterone therapy is useful in the treatment of male hypogonadism. Other

pharmacologic uses of androgens include:

A. male contraceptive

B. treatment of hereditary angioneurotic edema

C. treatment of precocious puberty in males

D. stimulation of erythropoiesis in patients with anemia of renal failure

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 1267 correct answer: 5 category: Endocrine

20. Gonadotropin releasing hormone (GNRH) analogs are available for use in

treating prostatic cancer. Other potential uses for GNRH analogs include:

1. treatment of female infertility

2. treatment of endometriosis

3. treatment of central precocious puberty

4. female and male contraception

5. All of the above

Item Number: 1274 correct answer: 1 category: Endocrine

21. Anti-estrogens are useful in the treatment of hormonally responsive breast

cancer. Agents which have anti-estrogenic activity at the estrogen receptor

include:

1. tamoxifen

2. norethynodrel

3. goserelin

4. ketoconazole

5. aminoglutethimide

Item Number: 1367 correct answer: 5 category: Endocrine

22. Diethylstilbestrol is a synthetic estrogen. It's actions include:

1. it retains estrogenic activity when administered orally

2. it is degraded slower by the liver than is estradiol

3. its use during pregnancy is contraindicated due to an association with

vaginal clear cell carcinoma in the offspring of mothers who took it while pregnant to prevent habitual or threatened abortion

4. it has been used as postcoital contraceptive

5. All of the above

Item Number: 11057 correct answer: 5 category: Endocrine

23. Statements which correctly describe the pharmacokinetics of insulin include:

1. the volume of distribution of insulin is extracellular fluid

2. insulin undergoes first-pass hepatic metabolism

3. insulin is filtered by the renal glomeruli and reabsorbed by the tubules, which also degrade it

4. the half-life of IV insulin is less than 9 minutes

5. All of the above

Item Number: 11061 correct answer: 5 category: Endocrine

24. Gastrointestinal hormones which are responsible for greater insulin activity after an oral glucose load than an intravenous glucose load include:

1. GIP

2. gastrin

3. pancreozymin-cholecystokinin

4. secretin

5. All of the above

Item Number: 11062 correct answer: 3 category: Endocrine

25. The metabolic actions of insulin may be described as:

1. increased rate of transport of glucose into the brain

2. increased conversion of protein to glucose

3. inhibition of hormone-sensitive lipase

4. enhanced glycogenolysis

5. enhanced glycosuria

Item Number: 11066 correct answer: 2 category: Endocrine

26. Select the correct row:

INSULIN ONSET(HR) PEAK DURATION

1. ultralente 1-2 4-6 18-24

2. regular «-1 2-4 5-8

3. NPH 1-1« 6-10 15-20

4. lente 4-6 16-18 20-36

5. semilente 1-2 6-12 12-18

1. A,B,C

2. A,C

3. B,D

4. D only

5. All of the above

Item Number: 11072 correct answer: 4 category: Endocrine

27. Potential side effects of therapy with chlorpropamide include all of the following EXCEPT:

1. SIADH (syndrome of inappropriate ADH secretion)

2. "Antabuse reaction"

3. skin rash

4. lactic acidosis

5. hypoglycemia

Item Number: 11084 correct answer: 5 category: Endocrine

28. Statements which explain the mechanism of action of oral sulfonylurea agents include all of the following EXCEPT:

1. decreased hepatic glucose production

2. increased tissue sensitivity to insulin

3. increased insulin binding to the insulin receptor

4. correction of post-receptor defects which contribute to insulin

5. regenerate beta cells of the pancreas

Item Number: 5146 correct answer: 4 category: Endocrine

29. Hyponatremia has been associated with carbamazepine and certain oral hypoglycemic agents. Oral hypoglycemic agents which have been associated with

SIADH include:

1. glipizide

2. acetazolamide

3. tolazamide

4. chlorpropamide

5. acetohexamide