3 - PHARMACOKINETICS

Item Number: 11123 correct answer: 3 category: Pharmacokinetics

1. Correct statements about bioavailability include:

A. pertains to the rate and extent of drug absorption

B. for two dosage forms of a drug to be considered equally

bioavailable, the measured AUC for each drug must be equal

C. for two dosage forms of a drug to be therapeutically equivalent

they must be equally bioavailable

D. equally bioavailable dosage forms may not necessarily be

bioequivalent

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11125 correct answer: 4 category: Pharmacokinetics

2. Correct statements pertaining to first-order elimination kinetics include:

A. a constant amount of drug is eliminated per unit of time

B. this pattern of drug elimination is most likely when elimination

pathways are saturated

C. clearance will vary as blood concentrations change

D. for drugs following this elimination pattern, doubling the rate of

administration will yield a doubling of serum or plasma

concentration at steady-state

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11137 correct answer: 5 category: Pharmacokinetics

3. Correct statements pertaining to protein-binding include:

A. acidic drugs are most likely to be bound to albumin

B. the degree to which a drug is protein-bound in plasma will affect

its apparent volume of distribution

C. basic drugs are most likely to be bound to alpha 1-acid

glycoprotein

D. for highly protein-bound drugs, decreasing the extent of

protein-binding in plasma will enhance the rate of glomerular

filtration

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11145 correct answer: 3 category: Pharmacokinetics

4. Correct statements pertaining to elimination half-life include:

A. elimination half-life always increases as clearance decreases

B. knowledge of a drug's elimination half-life allows one to estimate

the time necessary for steady-state to be reached after starting

therapy

C. for drugs that follow first-order elimination kinetics, increasing

drug dosage will increase the elimination half-life

D. elimination half-life is the time required for the amount of drug

in the body to be reduced by 50%

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11152 correct answer: 1 category: Pharmacokinetics

5. Phase II (synthetic) reactions include:

A. glucuronidation

B. N-acetylation

C. O-methylation

D. hydrolysis

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 1168 correct answer: 4 category: Pharmacokinetics

6. Metabolic pathways which are subject to induction and inhibition by some

drugs include:

A. sulfate conjugation

B. acetylation

C. glycine conjugation

D. oxidation

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11169 correct answer: 5 category: Pharmacokinetics

7. Some drugs are hepatically metabolized and possess a high extraction ratio.

Correct statements concerning these drugs include:

A. these drugs are subject to extensive first-pass metabolism

B. inducing the hepatic microsomal enzyme system is not likely to

alter clearance substantially

C. clearance of these drugs is likely to be reduced in patients with

congestive heart failure

D. administration of these drugs parenterally will increase

bioavailability

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct

Item Number: 11182 correct answer: 2 category: Pharmacokinetics

8. J.B. is 55 KG, 38-year-old male smoker with acute exacerbation of COPD who is

started on theophylline in the ER. A loading dose of 300 mg is administered

over 30 minutes. Blood samples obtained 3 hours and 6 hours after the loading

dose revealed serum concentrations of 12.0 mg/L and 8.1 mg/L, respectively.

The elimination half-life of theophylline in this patient is:

1. 0.53 hours

2. 5.33 hours

3. 3.50 hours

4. 6.00 hours

5. 8.03 hours

Item Number: 11185 correct answer: 4 category: Pharmacokinetics

9. Gentamicin pharmacokinetics can be described using a 1 compartment model,

undergoes first order metabolism, and is entirely cleared from the body

unchanged by the kidneys. If a patient with a creatine clearance of 30 ml/min

is given gentamicin, correct statements include:

1. compared to an identical person with normal renal function (125 ml/min)

this patient's loading dose should be reduced by 75%

2. if this patient receives the same loading dose as an identical person

with normal renal function, this patient's blood concentration will be

approximately 4 times higher

3. a loading dose should not be given to individuals who will clear a drug

from their body more slowly than a normal population

4. this patient should receive the same loading dose of gentamicin as an

individual with normal renal function

Item Number: 11199 correct answer: 1 category: Pharmacokinetics

10. Correct statements pertaining to elimination half-life include:

A. if total body clearance of drug A remains constant and the volume

of drug A distribution is doubled, elimination half-life is

increased

B. if total body clearance of drug A is doubled and drug A volume of

distribution remains constant, elimination half-life is reduced

C. if a reduction in total body clearance of drug A is accompanied by

a corresponding reduction in drug A volume of distribution,

elimination half-life will remain unchanged

D. if a reduction in total body clearance of drug A is accompanied by

an increase in drug A volume of distribution, elimination half-

life will remain unchanged

1. A,B,C

2. A,C

3. B,D

4. D only

5. All are correct